PICO is a handy mnemonic for the key parts of a clinical question. Patient/Problem, Intervention, Comparison, Outcome. Sometimes resources about PICO use the term PICOT or PICOTTS instead. The additional letters stand for: Timeframe ; Type of study ; Setting
What is a systematic review? Cochranelibrary.com says "A systematic review attempts to identify, appraise and synthesize all the empirical evidence that meets pre-specified eligibility criteria to answer a given research question." -- http://www.cochranelibrary.com/about/about-cochrane-systematic-reviews.html
How to appraise a clinical trial, by Dr. Eric Strong, Stanford University. The three videos below provide an overview of how to read and critically evaluate a clinical trial, prior to applying the information to your patient. Included is a discussion of the importance of randomization, controls, blinding, allocation concealment, proper sample size, and more.
Please note when you choose a database from this list, it closes the research guide page, and redirects you to the database page. To keep the research guide "open" while you access your chosen database, please hold the CTRL key down while you click the database link.
Just what is "Grey" literature? The 4th International Conference on Grey Literature (Washington D.C. : 1999) defined grey literature thusly: "That which is produced on all levels of government, academics, business and industry in print and electronic formats, but which is not controlled by commercial publishers."
"Grey Literature is any literature that has not been published through traditional means. It is often excluded from large databases and other mainstream sources." -- http://guides.library.utoronto.ca/c.php?g=251026&p=1672784
In addition to the specific videos listed below, you can find more tutorial videos in Youtube. Look for those tutorials that have been created by database providers such as EBSCO, Proquest, Credo, and by reputable Universities and Colleges.