- Diethylstilbestrol (DES) and CancerNIH (National Cancer Institute)
- COMPOUND SUMMARY DiethylstilbestrolPubChem, National Library of Medicine
- Diethylstilbestrol (DES) in the US"The Embryo Project Encyclopedia is a digital and Open Access publication of the Embryo Project. Begun in 2007, the Encyclopedia and the Embryo Project are funded by the US National Science Foundation in Washington D.C., and by Arizona State University in Tempe, Arizona. The Embryo Project is a collection of researchers who study the historical and social contexts of developmental and reproductive biology." --The Embryo Project Encyclopedia
- The Cutter Incident: How America's First Polio Vaccine Led to a Growing Vaccine CrisisFitzpatrick, Michael. “The Cutter Incident: How America's First Polio Vaccine Led to a Growing Vaccine Crisis.” Journal of the Royal Society of Medicine vol. 99,3 (2006): 156.
- Historical Vaccine Safety Concerns (CDC)Topics include: the Cutter Incident, Simian virus 40, Swine flu vaccine and Guillain-Barre Syndrome, Hepatitis B vaccine and Multiple Sclerosis, Rotavirus vaccine and intussusception, GBS and Meningococcal vaccine, Hib vaccine recall, H1N1 Influenza vaccine and narcolepsy, Porcine circovirus in rotavirus vaccines, and the HPV vaccine recall.
- Past vaccine disasters show why rushing a coronavirus vaccine now would be 'colossally stupid'CNN, by Jen Christensen, 9/1/2020. Discusses the current development of COVID vaccines. Included here for information about the 1955 Cutter Incident.
- [Dr. Frances O. Kelsey, head-and-shoulders portrait, facing front, addressing the Senate Government Operations subcommittee concerning Thalidomide]1962 August 1. Dr. Frances Oldham Kelsey was a pharmacologist who worked for the Food & Drug Administration; in her work she was instrumental in preventing the distribution in the United States of the sedative Thalidomide, which was responsible for severe birth defects in babies born in Europe. - United Press International telephoto. cph 3c31535 //hdl.loc.gov/loc.pnp/cph.3c31535
- Dr. Frances Kathleen Oldham Kelsey
U.S. National Library of Medicine - The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’By Leila McNeill, smithsonianmag.com, 5/8/2017
- Protecting the Public: Profile of Dr. Frances Oldham Kelsey"That Dr. Frances Oldham Kelsey saved countless lives and prevented numerous physical deformities of infants and children is a remarkable accomplishment in any career. More remarkable still is the fact that she accomplished this feat not through the discovery of a cure, the development of an innovative surgical procedure, or the invention of a life-saving device. Rather, it was Dr. Kelsey's professional behavior—her unwillingness to compromise the priorities of patient health and safety—that single-handedly averted an appalling tragedy nearly thrust upon an unsuspecting American public." -- AMA Journal of Ethics, Karen Geraghty, Virtual Mentor. 2001;3(7): doi: 10.1001/virtualmentor.2001.3.7.prol1-0107.
- How one scientist averted a national health crisis
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TED-ED video, posted to YouTube 6/7/2018 - Kefauver-Harris Amendments Revolutionized Drug Development"Landmark legislation was signed into law by President John F. Kennedy that established the scientific safeguards used today by the Food and Drug Administration (FDA) to ensure that consumers will not be the victims of unsafe and ineffective medications." -- FDA
- President Kennedy Calls For Stronger Drug Laws (1962)
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"President John F. Kennedy calls for stronger drug laws and attacks the use of thalidomide, in Washington DC, United States of America (USA)." -- British Pathé, posted to YouTube 4/13/2014. - THE THALIDOMIDE TRAGEDY: LESSONS FOR DRUG SAFETY AND REGULATIONHelix, By: Bara Fintel, Athena T. Samaras, Edson Carias, Jul 28, 2009
- The Thalidomide tragedy: Reminding us why research ethics oversight is here to stayResearch ethics blog by Nancy Walton, P.D.
- ThalidomideScience Museum (London England)
- Thalidomide complaints came earlyThe Blade, Toledo, Ohio, Sun, Jun 30, 1968 (Google News)
- Why did thalidomide’s makers ignore warnings about their drug?Theconversation.com, December 7, 2015
In 1998, the FDA approved Thalidomide for certain conditions, but NOT for use in pregnant persons.
- The Rise, Fall and Subsequent Triumph of Thalidomide: Lessons Learned in Drug DevelopmentRehman, Waqas et al. “The rise, fall and subsequent triumph of thalidomide: lessons learned in drug development.” Therapeutic advances in hematology vol. 2,5 (2011): 291-308. doi:10.1177/2040620711413165
- Drug Approval Package - Thalomid (Thalidomide)Thalomid (Thalidomide) Capsules, Company: Celgene Corp., Application No.: 020785, Approval Date: 07/16/1998. This drug comes with a warning that it can cause severe, life-threatening human birth defects
The Shadow of Thalidomide
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Call Number: e-FilmPublication Date: 2013"Summary: In the 1950s, thalidomide cut a wide swath of destruction across the world, leaving behind thousands of deformed infants, but that was only the beginning of the story." -- Films on Demand- The Thalidomide case by Call Number: e-BookISBN: 9781438181530Publication Date: 2018Explores the Thalidomide case, including the key issues, history of the case, summary of arguments, the verdict, the significance of the case, and readings for further study.
Why Dissent Matters by Call Number: e-BookISBN: 9780773550704Publication Date: 2017-06-01Frances Kelsey was a quiet Canadian doctor and scientist who stood up to a huge pharmaceutical company wanting to market a new drug - thalidomide - and prevented an American tragedy.
- Final Report of the Tuskegee Syphilis Study Ad Hoc Advisory PanelU.S. Department of Health, Education, and Welfare. Public Health Service. Final Report of the Tuskegee Syphilis Study Ad Hoc Advisory Panel. [Washington, D.C.: Government Printing Office]. 1972. HE 20.2:T 87. Indiana University Bloomington, Digital Archive
- 40 Years of Human Experimentation in America: The Tuskegee StudyMcGill University, Office for Science and Society, Ada McVean, 1/25/2019
- Racism and Research: The Case of the Tuskegee Syphilis StudyBrandt, Allan M. 1978. "Racism and research: The case of the Tuskegee Syphilis study." The Hastings Center Report 8(6): 21-29. Harvard Library Digital Access.
- U.S. Public Health Service Syphilis Study at TuskegeeCDC Centers for Disease Control and Prevention
- First, Do No Harm: The US Sexually Transmitted Disease Experiments in GuatemalaAm J Public Health. 2013 December; 103(12): 2122–2126.
Published online 2013 December. doi: 10.2105/AJPH.2013.301520 - "Ethically Impossible" STD Research in Guatemala from 1946 to 1948Presidential Commission for the Study of Bioethical Issues
- U.S. Public Health Service STD Experiments in Guatemala (1946–1948) and Their AftermathSpector‐Bagdady, K. and Lombardo, P.A. (2019), U.S. Public Health Service STD Experiments in Guatemala (1946–1948) and Their Aftermath. Ethics & Human Research, 41: 29-34. doi:10.1002/eahr.500010
- Advisory Committee on Human Radiation ExperimentsNational Security Archive, George Washington University
- DOE Openness: Human Radiation ExperimentsThis is a DOE Office of Environment, Health, Safety and Security, Office of Health and Safety Archived Website
- The Human Plutonium Injection ExperimentsLos Alamos Science, no. 23, 1995, William Moss and Roger Eckhardt
- Human Radiation ExperimentsAtomic Heritage Foundation, 7/11/2017
- HUMAN RADIATION EXPERIMENTS: The Department of Energy Roadmap to the Story and the RecordsUnited States Department of Energy, Assistant Secretary for Environment, Safety, and Health, February 1995
- LOS ALAMOS SCIENCE, NUMBER 23, SUMMER 1995 Radiation Protection and the Human Radiation ExperimentsLos Alamos National Laboratory Research Library
- Quaker Oats, MIT to pay $1.85 million Mass. residents were fed radiation-spiked cerealBoston Globe, Baltimore Sun, 12/31/1997
- The Secret 1949 Radiation Experiment That Contaminated WashingtonGizmodo, Sarah Zhang, 6/3/2015
- A Spoonful of Sugar Helps the Radioactive Oatmeal Go Down When MIT and Quaker Oats paired up to conduct experiments on unsuspecting young boysBy Lorraine Boissoneault, SMITHSONIANMAG.COM, MARCH 8, 2017
- Los Alamos Historical Document Retrieval & Assessment ProjectUniversity of New Mexico Research Guide
- An experimental study of the effect of evaluative labeling of speech fluencyMary Tudor, Master of Arts (MA); University of Iowa; 1939
DOI https://doi.org/10.17077/etd.9z9lxfgn
Also known as the "Monster Study" - Ethics and Orphans: The `Monster Study'BY JIM DYER, Mercury NewsPublished Sunday, June 10, 2001, in the San Jose Mercury News
- Huge payout in US stuttering caseBBC News, 8/17/2007
- The "Monster Study"Franklin H. Silverman, J. Fluency Disord. 13 (1988), 225-231
- The Stuttering Doctor's 'Monster Study'New York Times Magazine, by Gretchen Reynolds, 4/16/2003
- Iowa to pay subjects $925K for stuttering studyNBC News, updated 8/17/2007 8:43:33 PM ET
- “Sane in Insane Places,” 50 Years LaterPsychology Today, David Hellerstein M.D., reviewed by Devon Frye, posted 5/16/2022
- Good Ethics Can Sometimes Mean Better Science: Research Ethics and the Milgram ExperimentsMcArthur, D. (2009). Good Ethics Can Sometimes Mean Better Science: Research Ethics and the Milgram Experiments. Science & Engineering Ethics, 15(1), 69–79. https://doi.org/10.1007/s11948-008-9083-4
- Beyond Milgram : Obedience and Identity
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In early 1961 a young Yale University psychologist conducted a series of experiments that revealed a shocking truth to the world: ordinary people would do extraordinary acts of harm if ordered to do them by someone in authority. And for the following 40 years the standard interpretation of Stanley Milgram's research was that it clearly demonstrated unquestioning "obedience to authority". More-recently, however, researchers such as Haslam and Reicher have questioned this idea. In this film, using a range of data from the original study, they take us "beyond Milgram" to explore a very different interpretation of his research - one that focuses as much on disobedience as obedience. - Ethics in Psychological Research
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Streaming media title. 2013, distributed by Infobase, 2016. " This program discusses the importance of ethics in research and presents an overview of research studies that have raised ethical issues, including Milgram's obedience study, the Tuskegee studies, and Zimbardo's prison study. The program looks at such elements of ethical research as informed consent, right to privacy, right to withdraw, and debriefing."--library catalog record - Debunking the Stanford Prison ExperimentLe Texier, T. (2019). Debunking the Stanford Prison Experiment. American Psychologist, 74(7), 823–839. https://doi.org/10.1037/amp0000401
- Teaching scientific thinking using recent archival revelations about the Stanford Prison ExperimentGriggs, R. A., & Bartels, J. M. (2019). Teaching scientific thinking using recent archival revelations about the Stanford Prison Experiment. Psychology Teaching Review, 25(2), 39–47
- Quiet rage: the Stanford prison study
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Summary: "Describes an experiment in prison psychology. In the summer of 1971, Philip Zimbardo, Craig Haney, and Curtis Banks carried out an experiment to test a simple question: What happens when you put good people in an evil place? Does humanity win over evil, or does evil triumph? College student volunteers were pretested and randomly assigned to play the role of prisoner or guard in a simulated prison at Stanford University." -- library catalog record.
- Obedience to Authority : current perspectives on the Milgram paradigm by Call Number: e-BookISBN: 0585226326Publication Date: 2000-01-01
- Sulfanilamide DisasterFDA Consumer magazine. 6/1981, by Carol Ballentine
- Elixirs, diluents, and the passage of the 1938 Federal Food, Drug and Cosmetic ActWax, P. M. (1995). Elixirs, diluents, and the passage of the 1938 Federal Food, Drug and Cosmetic Act. Annals of Internal Medicine, 122(6), 456–461. https://doi.org/10.7326/0003-4819-122-6-199503150-00009
- Piltdown ManNatural History Museum
- Study reveals culprit behind Piltdown Man, one of science’s most famous hoaxesSciencemag.org, By Michael Price, Aug. 9, 2016
- Solving the Piltdown Man Scientific FraudScientific American, By Isabelle De Groote, The Conversation on August 10, 2016
- In Search of History. The Piltdown Man
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Call Number: e-FilmPublication Date: 2010, c1997 - Britain's Greatest Hoax
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Call Number: e-FilmPublication Date: 2019, c2003
- BMJ Author Video - Study329
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Vimeo video, Dr. Jon Jureidini, Clinical Professor, Critical and Ethical Mental Health Research Group, University of Adelaide, Adelaide, Australia - GlaxoSmithKline faces US lawsuit over concealment of trial resultsDyer O. (2004). GlaxoSmithKline faces US lawsuit over concealment of trial results. BMJ (Clinical research ed.), 328(7453), 1395. https://doi.org/10.1136/bmj.328.7453.1395
- GlaxoSmithKline to Plead Guilty and Pay $3 Billion to Resolve Fraud Allegations and Failure to Report Safety Data"GSK agreed to plead guilty to a three-count criminal information, including two counts of introducing misbranded drugs, Paxil and Wellbutrin, into interstate commerce and one count of failing to report safety data about the drug Avandia to the Food and Drug Administration (FDA)." -- United States Department of Justice, Office of Public Affairs, 7/2/2012
- No academic matter: Study links retractions to patient harmRetractionWatch, Adam Marcus, 6/13/2011
- No correction, no retraction, no apology, no commentDoshi P. No correction, no retraction, no apology, no comment: paroxetine trial reanalysis raises questions about institutional responsibility BMJ 2015; 351 :h4629 doi:10.1136/bmj.h4629
- Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescenceLe Noury J, Nardo J M, Healy D, Jureidini J, Raven M, Tufanaru C et al. Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence BMJ 2015; 351 :h4320 doi:10.1136/bmj.h4320
- Study 329BMJ 2015;351:h4973
doi: https://doi.org/10.1136/bmj.h4973 (Published 17 September 2015) - Study 329 [Wikipedia article]"Study 329 was a clinical trial which was conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant, in treating 12- to 18-year-olds diagnosed with major depressive disorder ... study 329 became controversial when it was discovered that the article had been ghostwritten by a PR firm hired by SmithKline Beecham; had made inappropriate claims about the drug's efficacy; and had downplayed safety concerns." -- Wikipedia
- The Truth About "Study 329"Psychology Today, Christopher Lane, 9/16/2015
- The Controversial Study of Twins and Triplets Adopted and Reared ApartPsychology Today blog post, by Nancy L. Segal, reviewed by Abigail Fagan
- Experiment on identical siblings separated at birth: ethical implications for researchers, universities, and archives todayAbstract only. Klitzman, R. L., & Kelmenson, A. M. (2020). Experiment on identical siblings separated at birth: ethical implications for researchers, universities, and archives today. Journal of Medical Ethics. https://doi.org/10.1136/medethics-2019-105983
- Journalist On Discovering The Study Of The ‘Three Identical Strangers’ Triplets
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Megyn Kelly Today, 7/12/2018 (Youtube video) - Records from controversial twin study sealed at Yale until 2065Yale News, William McCormack, 10/1/2018
- Three Identical Strangers: Precluding a real conversation about the ubiquity of self-deceptionPsychology Today, Leon Hoffman, Posted Aug 20, 2018
- Three Identical Strangers and The Twinning Reaction-Clarifying History and Lessons for Today From Peter Neubauer's Twins Studyoffman, L., & Oppenheim, L. (2019). Three Identical Strangers and The Twinning Reaction-Clarifying History and Lessons for Today From Peter Neubauer’s Twins Study. JAMA, 322(1), 10–12. https://doi.org/10.1001/jama.2019.8152
- ‘Three Identical Strangers’: It’s not too late to address the ethical violationsStatnews, Karen Glanz and Holly Fernandez Lynch, 2/7/2019
- Three identical strangersCall Number: SBU SPR DVD Disc 174.28 T4131Publication Date: 2018True story of three men who make the chance discovery, at the age of nineteen, that they are identical triplets, separated at birth and adopted to different parents.
- The Hans Eysenck affair: Time to correct the scientific recordArticle abstract. Marks, D. F. (2019). The Hans Eysenck affair: Time to correct the scientific record. Journal of Health Psychology, 24(4), 409–420. https://doi.org/10.1177/1359105318820931
- Inquiry into eminent psychologist failed to list many unsafe papers, biographer claimsArticle abstract. Hawkes, N. (2019). Inquiry into eminent psychologist failed to list many unsafe papers, biographer claims. BMJ (Clinical Research Ed.), 367, l6329. https://doi.org/10.1136/bmj.l6329
- Journals retract 13 papers by Hans Eysenck, flag 61, some 60 years oldRetraction Watch, Ivan Oransky, 2/20/2020
- Misconduct allegations push psychology hero off his pedestalScience, by Cathleen O'Grady, 7/15/2020
- Personality and fatal diseases: Revisiting a scientific scandalAnthony J. Pelosi, Journal of Health Psychology, Volume: 24 issue: 4, page(s): 421-439 Article first published online: February 22, 2019; Issue published: March 1, 2019 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/)
- Research misconduct complaints and institutional logics: The case of Hans Eysenck and the British Psychological SocietyCraig, Russell, et al. “Research Misconduct Complaints and Institutional Logics: The Case of Hans Eysenck and the British Psychological Society.” Journal of Health Psychology, Oct. 2020, doi:10.1177/1359105320963542.
The Doctor Who Fooled the World by Call Number: e-BookISBN: 9781421438016Publication Date: 2020-09-29
- Brian Deer's 2004 film on Andrew Wakefield
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Brian Deer YouTube video, posted 10/10/2014 - Brian Deer’s book on Andrew Wakefield: “The Doctor Who Fooled the World”For Better Science, by Leonid Schneider, 10/13/2020
- MMR doctor 'failed to act in interests of children'"The accusations relate to investigations for the study, based on 12 youngsters with bowel disorders, carried out between 1996 and 1998....
The GMC heard that vulnerable children were subjected to "inappropriate and invasive" tests by the doctors, who breached of "some of the most fundamental rules in medicine".Wakefield did not have paediatric qualifications and had not worked as a clinical doctor for several years when he ordered the tests, the panel was told. One of the key claims was that Wakefield accepted more than £50,000 from the Legal Aid Board for research to support a group of parents' attempts to fight for compensation....Wakefield was accused of paying children £5 for blood samples at his son's birthday party, then joking about it afterwards." -- theguardian.com, 1/28/2010 - HOW THE CASE AGAINST THE MMR VACCINE WAS FIXEDDeer Brian. (2011). How the Case against the Mmr Vaccine Was Fixed. BMJ: British Medical Journal, 342(7788), 77–82.
- Andrew Wakefield’s vaccine patentWakefield "secretly filed a patent application in London claiming to have discovered his own, allegedly safer, single shot.] -- briandeer.com
- Assessment of Citations of the Retracted Article by Wakefield et al With Fraudulent Claims of an Association Between Vaccination and AutismSuelzer EM, Deal J, Hanus KL, Ruggeri B, Sieracki R, Witkowski E. Assessment of Citations of the Retracted Article by Wakefield et al With Fraudulent Claims of an Association Between Vaccination and Autism. JAMA Netw Open. 2019;2(11):e1915552. doi:10.1001/jamanetworkopen.2019.15552
- Fostering Integrity in Research, Appendix D. Detailed Case Histories.Information about the following cases: Wafefield MMR-Autism, PAXIL, Univ. of Wisconsin Goodwin case, the Hwang stem cell case, the Translational omics case, The Riken-Stap case. National Academies of Sciences, Engineering, and Medicine. 2017. Fostering Integrity in Research. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/21896.
- Injecting fear: does the MMR shot cause autism?
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"A link between autism and the Measles-Mumps-Rubella shot has been largely refuted by the medical establishment. But some doctors, along with many parents of autistic children, remain convinced of a connection. This program sifts through both sides of the issue, fully explaining both the link theory and the epidemiological research that vindicates the MMR. Interviews with Dr. Andrew Wakefield-the gastroenterologist who first asserted that the vaccine can cause intestinal infections and lead to brain damage-accompany moving testimony from families affected by autism, as well as extensive commentary from skeptical physicians." -- video description - Lessons Learned from Publicizing and Retracting an Erroneous Hypothesis on the Mumps, Measles, Rubella (MMR) Vaccination with Unethical ImplicationsKhan H, Gasparyan AY, Gupta L. Lessons Learned from Publicizing and Retracting an Erroneous Hypothesis on the Mumps, Measles, Rubella (MMR) Vaccination with Unethical Implications. J Korean Med Sci. 2021;36(19):e126. https://doi.org/10.3346/jkms.2021.36.e126